Anomalous mechanosensitive ion transport in nanoparticle-blocked nanopores

Living organisms can sense extracellular forces via mechanosensitive ion channels, which change their channel conformations in response to external pressure and regulate transport through the cell membrane. Such pressure-regulated is critical for various biological processes, such as cellular turgor control hearing mammals, but has yet be achieved artificial systems using similar mechanisms. In this work, we construct a nanoconfinement by reversibly blocking single nanopore with nanoparticle report anomalous ultra-mechanosensitive ionic across resulting upon assorted mechanical electrical stimuli. Our observation reveals suppressed conduction system applied increases, imitates certain behaviors of stretch-inactivated channels systems. Moreover, pressure-induced current rectification also observed despite high concentration solution. Using combined experimental simulation study, correlate both phenomena rotation physical structure blocked nanopore. This work presents nano-confinement requiring minimal fabrication techniques provides new opportunities bio-inspired nanofluidic applications.